Making stop motion videos in a genetics class

23 Apr

2017-04-17 09.49.23

Last week, the students in my genetics class made stop motion videos. They had to do some preparation as homework (mainly thinking about a topic), but other than that, they just had 50 minutes to make a movie. I expected that most would not finish it in that time, but they get extra credit if they finish it at home.

From my colleague Kimberly Tanner from the Science Education Partnership and Assessment Laboratory (SEPAL), I have learned to collect feedback from students very often during the semester, so I asked them: Did you learn from Monday’s class?

Probably 90 students made a stop motion video in the two sections of my genetics class on Monday. 54 of them wrote feedback on Wednesday. 32 of 54 (59%) thought they learned something about genetics!

32 students felt like they learned something about genetics

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6 students thought it was “just review”

I think that review is very useful!

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8 students felt like they learned about how to make a stop motion video

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8 students felt like they didn’t learn anything

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Will I do this again?

Yes! Definitely!

But I may talk to students more about how this exercise will benefit their learning and encourage students to pick a topic they would like to review.

 

 

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I drew an animation video

15 Apr

Evolutionary rescue and soft sweeps

A drawn animation movie! When I was a kid I wanted to work for Disney, so this is a dream come (a little bit) true!

The paper is here.

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Marching for science with colleagues and students

14 Apr

MarchForSciencePDF

Over 22,000 Participants Enrolled in PrEP Trials

24 Mar
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Overview of eleven different PrEP Trials divided into treatment arms. Trials are organized by total number of participants.

Link to Larger Figure

Pre-Exposure Prophylaxis, or PrEP, is a medication that prevents HIV infection. It is intended to be used together with safer sex practices (e.g., condoms). This stacked barplot shows the number of participants in 11 different PrEP studies. The earliest study in the plot is the West Africa trial, which was initiated in 2004. Each bar corresponds to its labeled trial. The different colored sections in each bar represent the “arms” or “cohorts” of the study. Most studies have a placebo cohort and a treatment cohort. The PROUD study only has the treatment arm. The VOICE study has three different treatment arms, while the Partners PrEP study has two different treatment arms.

The light blue color represents the Truvada (emtricitabine/tenfovir disoproxil fumarate combination) cohorts. The dark blue color represents the cohort only given TDF (tenofovir disoproxil fumarate), and the off-white color represents the placebo cohort. The light green and pink colors represent the 1% Tenofovir vaginal gel cohort and placebo vaginal gel cohorts, respectively. The blue pill icon over a graph indicates the study employed a daily oral pill to be used as PrEP. The green gel icon indicates the study employed a topical vaginal gel to be used as PreP. We can see that all of the individuals enrolled in the studies give a combined total of over 22,000 participants. Even though PrEP is a relatively new preventative, the plot shows that a large number of participants have already enrolled in PrEP trials and the prophylaxis is becoming well studied.

About the Author

Dwayne Evans is a graduate student at SFSU. He works on HIV drug resistance in relation to Pre-Exposure Prophylaxis (PrEP). He made a figure to show how many people participated in PrEP trials since 2004.

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Dwayne Evans, SFSU

References

(Please click on the reference for a link to the study)

VOICE Trial

Marrazzo JM, Ramjee G, Chirenje ZM, et al. Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women. N Engl J Med 2015; 372:509-518.

Partners PrEP Study

Baeten JM, Donnell D, Celum C, et al. Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women. N Engl J Med 2012; 367:399-410

Donnell D, Baeten JM, Celum C, et al. HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention. J Acquir Immune Defic Syndr 2014; 66: 340-348

Ndase P, Celum C, Baeten JM, et al. Successful discontinuation of the placebo arm and provision of an effective HIV prevention product after a positive interim efficacy result: the partners PrEP study experience. J Acquir Immune Defic Syndr 2014; 66:206-12

iPrEx Study

Grant RM, Lama JR, Glidden DV, et al. Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men. N Engl J Med 2010; 363:2587-99

Liegler T, Abdel-Mohsen M, Grant RM, et al. HIV-1 Drug Resistance in the iPrEx Preexposure Prophylaxis Trial. J Infect Dis 2014; 210:1217-27

Bangkok Tenofovir Study

Choopanya K, Martin M, Vanichseni S, et al. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomized, double-blind, placebo-controlled phase 3 trial. The Lancet 2013; 381:2083-90

FEM-PREP Study

Van Damme L, Corneli A, Taylor D, et al. Preexposure Prophylaxis for HIV Infection among African Women. N Engl J Med 2012; 367:411-422

TDF2 Study

Thigpen MC, Kebaabetswe PM, Brooks JT, et al. Antiretroviral Preexposure Prohpylaxis for Heterosexual HIV Transmission in Botswana. N Engl J Med 2012; 367:423-434

Chirwa LI, Johnson JA, Brooks JT, et al. CD4(+) cell count, viral load, and drug resistance patterns among heterosexual breakthrough HIV infections in a study of oral preexposure prophylaxis. AIDS 2014;28:223-6

West Africa Study

Peterson L, Taylor D, Cates W, et al. Tenofovir Disoproxil Fumarate for Prevention of HIV Infection in Women: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial. PLoS Clin Trials 2007; 2:e27

CAPRISA 004 Trial

Mansoor LE, Abdool Karim Q, Yende-Zuma N, et al. Adherence in the CAPRISA 004 Tenofovir Gel Microbicide Trial. AIDS Behav 2014; 18:811

PROUD Study

McCormack S, Dunn DT, Gill ON, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomized trial. The Lancet 2015; 387:53-60

IPERGAY Study

Molina JM, Capitant C, Delfraissy JF, et al. On Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection. N Engl J Med 2015;373:2237-2246

US MSM Trial

Liu A, Vittinghoff E, Buchbinder S, et al. Sexual risk behavior among HIV-uninfected men who have sex with men (MSM) participating in a tenofovir pre-exposure prophylaxis (PrEP) randomized trial in the United States. J Acquir Immune Defic Syndr 2013; 64:87-94

On executive orders and protest fatigue

5 Feb
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Poster by Shephard Fairey / ObeyGiant.com via Amplifier Foundation

This thoughtful post was written by my friend Arne Bakker who works at Stanford. He allowed me to post it here. Pleuni

So, I spent part of my night listening to legal experts of the Stanford Law School discussing the impact of 3 recent executive orders by President Trump. It was pretty impressive, with some of the top legal scholars of the country being present. I learned about Executive Order #1 (by Lincoln), and about an Executive Order actually describing what an Executive Order is (Chicken, meet Egg). And I learned a lot about how these orders are affecting thousands of people inside and outside the US, which brought tears to our eyes and fear in our hearts.

But I also learned from these pretty amazing people what they think we can (and should) do:

***First, there was the positive reminder that after 9/11 the courts allowed many laws impacting civil liberties to pass because of broad ‘national security’ concerns, but that today it looks like the courts are actually resisting the policy changes from the Trump administration. Keeping my fingers crossed for that one.

***Second, there was the heartfelt plea to not just rely on the courts, but to continue calling your representatives to resist these policies and remain active and vocal in your protests. It actually works, people! These top legal experts attributed the recent changes in allowing permanent residents to enter the country and backtracking on some other provisions purely to the quick and vocal response of thousands of people after the Executive Orders went into effect less than a week ago.

***Third, they cautioned for protest fatigue. There is a real agenda for controlling the news cycle with new shock after new shock to wear us out. As someone said, don’t fall for forgetting yesterday’s news because of today’s new shocker. Think hard about what issue you deeply care about and keep track of it, even when the news cycle has moved on. Keep reminding people, give them updates on policy changes, victories and losses where you can. And don’t be upset if someone else knows less about ‘your thing’ and is vocal about a different issue that they care deeply about. Learn from them, since they will keep track of those issues and can share their knowledge with you.

 

If you are interested to read more on the travel ban by Stanford professors, see here: https://law.stanford.edu/2017/02/01/the-new-travel-ban-national-security-and-immigration/

 

Appalled by Trump actions

28 Jan

I am appalled by what is happening in the US since Trump, Pence and the Republican Party are in charge. I believe that women should have access to safe abortions and birth control. I believe everyone has the right to affordable medical insurance. I believe refugees should be welcomed in this country. (Soon, we may need other countries to welcome refugees from the United States!) I believe scientists who work for the government should be free to speak their minds and share their findings with the world. I believe no one should be banned from this country based on their religion. I belief that Black Lives Matter.

I will do everything I can to provide a safe space in my classrooms and my lab for everyone, regardless of their race, religion, gender, sexual orientation, immigration status or physical abilities.

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In defense of science

28 Jan

I (Pleuni Pennings) endorse the following, which was drafted by Graham Coop (UC Davis), Michael Eisen (UC Berkeley) and Molly Przeworski (Columbia):

We are deeply concerned by the Trump administration’s move to gag scientists working at various governmental agencies. The US government employs scientists working on medicine, public health, agriculture, energy, space, clean water and air, weather, the climate and many other important areas. Their job is to produce data to inform decisions by policymakers, businesses and individuals. We are all best served by allowing these scientists to discuss their findings openly and without the intrusion of politics. Any attack on their ability to do so is an attack on our ability to make informed decisions as individuals, as communities and as a nation.

If you are a government scientist who is blocked from discussing their work, we will share it on your behalf, publicly or with the appropriate recipients. You can email us at USScienceFacts@gmail.com.

If you use this email address, here is a PGP public key for PGP encryption: http://pgp.mit.edu/pks/lookup?op=get&search=0x52C7139DE0A3D350