Tag Archives: polio

15 papers on contemporary evolution in human viruses

29 May

In the fall semester of 2014 I taught a reading seminar for master students at SF State on contemporary evolution in human viruses. This blog post contains a list of the papers we read in the seminar.

I posted about this seminar previously here (about the seminar format) and here (no powerpoint allowed), and here (about being nervous for a talk).

The students’ work can be read and seen here (about H1N5), here (polio outbreak), here (Dengue), here (Ebola), here (HIV in court), here (doing my own homework), here (the origin of HIV), here (on bad small things) and here (Hep B).

These are the papers we read:

1. Fast evolution of drug resistance in HIV patient the 1980s

ReissLangeLancet

Resumption of HIV antigen production during continuous zidovudine treatment. Lancet. 1988 Feb 20;1(8582):421.
Reiss P, Lange JM, Boucher CA, Danner SA, Goudsmit J.

2. HIV: Doctor infects his ex-girlfriend, phylogenetic evidence in court

Metzker_HIV_criminalcase

Metzker, Michael L., et al. “Molecular evidence of HIV-1 transmission in a criminal case.” Proceedings of the National Academy of Sciences 99.22 (2002): 14292-14297.

3. Very contemporary: the genomics of the West-African Ebola epidemic

Gire_Ebola

Gire, Stephen K., et al. “Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.” Science 345.6202 (2014): 1369-1372.

4. Using phylogenetics to determine origin of Dengue-3 outbreak in Australia

RitchieDENV
An explosive epidemic of DENV-3 in Cairns, Australia. PLoS One. 2013 Jul 16;8(7):e68137. doi: 10.1371/journal.pone.0068137. Print 2013. Ritchie SA1, Pyke AT, Hall-Mendelin S, Day A, Mores CN, Christofferson RC, Gubler DJ, Bennett SN, van den Hurk AF.

5. Classic paper from Beatrice Hahn’s lab on origin of HIV-1

Gao_HIV

Gao, Feng, et al. “Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes.” Nature 397.6718 (1999): 436-441.

6. Timing the start of the HIV-1 pandemic

Korber_HIVTiming

Korber, Bette, et al. “Timing the ancestor of the HIV-1 pandemic strains.”Science 288.5472 (2000): 1789-1796.

7. Where did the polio outbreak in Dominican Republic and Haiti come from?

KewEtAlPolio

Kew, Olen, et al. “Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.” Science 296.5566 (2002): 356-359.

8. Within-patient evolution of vaccine-derived polio virus

Martin_Polio

Martín, Javier, et al. “Evolution of the Sabin strain of type 3 poliovirus in an immunodeficient patient during the entire 637-day period of virus excretion.”Journal of Virology 74.7 (2000): 3001-3010.

 9. Hepatitis B within-patient evolution

LimRodrigo

Lim, Seng Gee, et al. “Viral quasi-species evolution during hepatitis Be antigen seroconversion.” Gastroenterology 133.3 (2007): 951-958.

10. Permissive mutations and the evolution of drug resistance in Influenza

Bloom_Influenza

Bloom JD, Gong LI, Baltimore D. Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance. Science (New York, NY). 2010;328(5983):1272-1275. doi:10.1126/science.1187816.

11. Controversial experiments on H5N1 Influenza

HerfstInfluenza

Airborne transmission of influenza A/H5N1 virus between ferrets. Science. 2012 Jun 22;336(6088):1534-41. doi: 10.1126/science.1213362.
Herfst S1, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus AD, Fouchier RA.

12. Influential study on treatment to prevent HIV

GrantEtAlHIV

Grant, Robert M., et al. “Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.” New England Journal of Medicine 363.27 (2010): 2587-2599.

 13. HIV drug resistance in women in Africa who were treated to prevent mother-to-child transmission

Eshleman_NVPHIV

Eshleman, Susan H., et al. “Nevirapine (NVP) resistance in women with HIV-1 subtype C, compared with subtypes A and D, after the administration of single-dose NVP.” Journal of Infectious Diseases 192.1 (2005): 30-36.

 14. Evolution of Acyclovir resistance in Varicalla-Zoster Virus

Morfin_VZV

Morfin, Florence, et al. “Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir.”Antimicrobial agents and chemotherapy 43.10 (1999): 2412-2416.

 

15. Soft and hard sweeps during evolution of drug resistance in HIV

Pennings2014
Loss and recovery of genetic diversity in adapting populations of HIV. PLoS Genet. 2014 Jan;10(1):e1004000. doi: 10.1371/journal.pgen.1004000. Epub 2014 Jan 23.
Pennings PS1, Kryazhimskiy S2, Wakeley J3.

Students write about a vaccine-derived polio outbreak

16 Oct

Last week we read a paper about an outbreak of vaccine-derived polio virus in Dominican Republic and Haiti in 2000 – 2001. Such outbreaks are uncommon, but they do happen. For me, this paper made clear that no vaccine is 100% safe. As an evolutionary biologist, I find it exciting that it may be possible to study how the attenuated virus evolves to become virulent again.

Here is some of the homework from the students in my class.

Make a graphical abstract of the paper

CameronSoulette

Cameron Soulette

What kind of data are used in the paper?

Most of the data used in this paper were viral isolates obtained from the stool samples of two patients in the Dominican Republic and Haiti. These were collected (presumably) by the authors because the patients were exhibiting signs of Acute Flaccid Paralysis (AFP). Individuals can have nonpolio AFP, but these two patients were exhibiting characteristics that led the authors to believe their AFP was caused by wild poliovirus, of which very few infections had been observed since the 1980’s.

Nucleic acid probe hybridization identified Vaccine-Derived Polio Virus (VDPV) in these samples. They then performed a sequence characterization of the major capsid surface protein VP1 and compared the isolates from samples to wild-type. The authors looked for more polio cases in the area, and obtained 31 more samples from which they isolated VDPV. They used bioinformatic approaches to analyze their data, including maximum-likelihood and neighbor-joining trees. Using these methods they were able to figure out the timeline for this outbreak of the virus.

Jennifer Gilbert

How much impact did this paper have?

According to Google scholar, this paper has been cited 441 times with the most recent being this year. I found two articles about the paper: one from the Telegraph and the other was a story from Reuters Health (I could not find the original article, but I found it on two separate forums). I think this paper is very influential, but it also has the potential to be used in ways that the authors did not intend. The paper emphasizes the need for continued vaccination and increased surveillance to further the effort of poliomyelitis eradication. However, it seems that this paper has also been picked up as fodder for those in the anti-vaccination movement (one of the forums was hosted by a group called The American Iatrogenic Association – a group focused on raising awareness for illness/ injury caused by physicians).

Links to articles:

http://www.telegraph.co.uk/news/worldnews/centralamericaandthecaribbean/dominicanrepublic/1387873/Vaccine-sparked-polio-outbreak.html

http://medtech.syrene.net/forum/showthread.php?466-Vaccine-Confirmed-as-Source-of-Polio-Outbreak-in-Haiti-Dominican

https://groups.yahoo.com/neo/groups/iatrogenic/conversations/topics/356

Bradley Bowser